Allergy Medication: What Works, What to Avoid, and How to Choose

When your nose runs, your eyes itch, or you can’t catch a full breath, allergy medication, a category of drugs designed to block or reduce the body’s reaction to allergens like pollen, dust, or pet dander. Also known as antihistamines, these are the go-to fix for millions who deal with seasonal or year-round allergies. But not all allergy meds are the same—and picking the wrong one can waste time, money, or even make things worse.

There are three main types you’ll actually need to know about: antihistamines, drugs that stop histamine, the chemical your body releases during an allergic reaction. Also known as H1 blockers, they’re what you find in pills like cetirizine or loratadine. Then there’s nasal corticosteroids, sprays that reduce swelling in the nose, often the most effective long-term solution for congestion and runny nose. These include fluticasone and mometasone—commonly prescribed because they work without making you drowsy. And finally, decongestants, short-term relief for blocked sinuses, often found in pills or nasal sprays like pseudoephedrine or oxymetazoline. But here’s the catch: nasal sprays can cause rebound congestion if used too long, and oral decongestants can spike your blood pressure. Most people don’t realize these aren’t meant for daily use. And while some OTC options help, others just mask symptoms without touching the root cause.

What you take depends on your symptoms. If it’s sneezing and itchy eyes, an antihistamine might be enough. If your nose is stuffed up all winter, a nasal spray is likely your best bet. And if you’re using a decongestant more than three days in a row, you’re probably making things harder on yourself. The posts below break down real comparisons—what works for eczema-related itching, why some allergy meds clash with blood pressure drugs, and how hydrocortisone can help or hurt your skin. No fluff. Just what you need to know to pick the right one—and avoid the ones that don’t.