If you’ve tried every over‑the‑counter acne product and still see stubborn breakouts, your doctor might suggest isotretinoin. It’s a powerful retinoid that targets the root causes of severe acne: excess oil, clogged pores, and inflammation. By shrinking the oil glands and speeding up skin turnover, isotretinoin can clear up even the toughest nodules in a few months.
Because it works so hard, isotretinoin is only prescribed for moderate to severe acne that hasn’t responded to other treatments. Your dermatologist will review your medical history, run a few lab tests, and explain the commitment needed – regular blood work, strict birth‑control measures for women, and close monitoring of side effects.
Doctors usually start with a low dose, often 0.5 mg per kilogram of body weight per day, and may increase to 1 mg/kg if needed. The goal is to reach a cumulative dose of about 120‑150 mg/kg over the entire course. Most people stay on isotretinoin for 4‑6 months, but some need a second round if acne returns.
Take the pill with food to improve absorption, and try to keep the schedule consistent – same time each day. Skipping doses can cause flare‑ups, while taking more than prescribed won’t speed up results and may raise the risk of side effects.
Dry skin, chapped lips, and nosebleeds are the most frequent complaints. A good lip balm, moisturiser, and a humidifier can make those symptoms manageable. More serious effects include high triglycerides, liver‑enzyme changes, and mood swings. That’s why your doctor will order blood tests at the start, after a month, and then every 4‑6 weeks.
Women of child‑bearing age must follow a strict pregnancy‑prevention program. Isotretinoin can cause severe birth defects, so you’ll need two reliable forms of contraception and monthly pregnancy tests while on the drug and for a month after stopping.
If you notice severe headache, vision changes, persistent joint pain, or intense sadness, call your doctor right away. Early detection of problems keeps the treatment safe and effective.
Never buy isotretinoin from an unverified online shop. Look for pharmacies that require a valid prescription, display a licence number, and are based in a country with strict pharmacy regulations. In the UK and EU, reputable online pharmacies will ask for a copy of your doctor’s prescription and may even arrange a tele‑consultation.
Before you order, check that the pharmacy offers a clear return policy, secure payment, and trackable shipping. If a price looks too good to be true, it probably is – counterfeit pills can be ineffective or dangerous.
Ask your dermatologist if they can send the prescription directly to a trusted online pharmacy. Many clinics partner with services that handle the paperwork for you, making the process smoother and less likely to involve errors.
Can I drink alcohol while on isotretinoin? It’s best to limit alcohol because both can stress the liver.
Will my skin stay clear after the course? Most people stay clear, but a small percentage need a second round or maintenance therapy.
Is it safe for teens? Yes, if a dermatologist supervises the treatment and follows the monitoring plan.
Isotretinoin can be a game‑changer for severe acne, but it demands respect and careful follow‑up. Talk to your dermatologist, stick to the dosing plan, and choose a reputable pharmacy – that’s the recipe for clear skin without unnecessary risks.
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